Absolutely. The best question is should that concern us.
Within the things that we discuss here their are a few concepts that come up that I seek clarity about when they arise.
Speaking of clarity, this blurb isn't about you or your question, I'm just yapping, hopefully maybe someone reading gets something from it.
I digress, back to denaturing and the concepts that come up. I actually haven't seen this in a while but in the past many times irl and on the boards someone will make a statement about protein, usually powder, denaturing due to age or some other reason. I will often challenge that person to explain why that would be bad and have always been met with either silence or an equivalent answer like "cause it's bad".
I make that challenge because I honestly want to understand if their is a problem. I've reached out to some experts in the field including someone who plays our game, Layne Norton. The simple reserved answer I have received from them is that by itself it's not a problem, from my own research I will even go a step further* and say it's a benefit. I think that those who believe it is a problem have an over simplified understanding of what it means.
Here's why, pardon my own oversimplification and shitty analogies.
Protein as most of us here will know is made up of "the building blocks" of amino acids. Ultimately, your digestive system must turn all protein into individual amino acids before they can enter your bloodstream and build muscle or be used for their other functions.
Whatever amino acids are making up a protein come tightly folded up in a package which makes them useless for performing their jobs. Think of that shelving unit you bought from IKEA that came in a flat cardboard box. (1)You have to cut open or unfold the box, then lay out the screws and brackets and individual shelf and support pieces out before you can (2) use them to (re)build something useful like a shelf so it can (3)do what shelves do
Denaturing is like that same (1)process, unfolding the protein so we can get down to the useful amino acids and put them to work. For general health and the purposes we discuss here Hydrochloric Acid in your stomach (1) opens the box/unfolds the protein. Enzymes, biochemical and other processes (2) build something useful by refolding the amino acids, reconstructing them so they can (3) build structures of muscle, connective tissue, skin etc.
It doesn't matter what causes the (1)denaturing, HCL, heat, time. It is simply the first and absolutely necessary step into making the amino acids useful. Besides being the first step in a human body it is also the first step in making amino acid supps, peptides and isolating specific AA's for all kinds of food products (MSG, Aspartame), Pharmaceuticals, pesticides.... the list goes on.
That's the ramble but the quickest way to "prove" to someone that denatured protein powder is not only a problem but actually a benefit is to ask them if they think the
Essential Amino Acids especially in supplement form are beneficial. (hint- it's in the name

)
*Consuming denatured protein means the first step has been done for you.