Nope, literally none of my bloodwork has ever come back with flags of high/high normal for any of my regular markers when using the gel. I honestly think it's the healthiest way to do TRT but I will admit, it is not as great as the injections especially for athletic performance/muscle gain.
It kept me really lean, I always have a 6 pack now but I am also quite skinny, but it beats being skinny fat. The usual side effects from low T like having no energy, sexual dysfunction were completely cured with the Androgel. Also no hair loss, even though I don't think I have a balding gene when I used TRT injections I definitely did see some hair loss although it wasn't that much I'd have more hair on my pillow, with the gel I have none. Also another thing is my blood pressure had no changes at all, stayed low.
I'd say my strength / athletic performance had no real boost, so it was kind of like just going back to having normal testosterone levels.