What is everyone's injection frequency on TRT??

Test E/D mix, every 5 days.
I prefer a half dose, 2x frequency IM shot schedule vs the full dose E10D of what I've been prescribed.

For me, that's ~65mg total ester, E5D... Rather than my endo's preferred (and Rx'd) schedule of 125mg Test-C E10D.
Yes, I'm aware 125mg-C/e10D is an odd (underdosed) schedule, but literature does support an endogenous production of Test around the 7mg/day range, which does line up better with a 375mg(esterified) total dosing per month... And my endo is extremely "by the book."

I had horrible withdrawal irritability and acne on an E10D dosing schedule.
 
I started every other day about two months ago and have stopped taking aromasin entirely.

Huberman talked about this on a podcast and it really does seem to work well. Using small 1 ml 25g pins and with small volume it’s easy to inject all over the place. Did pecs for the first time a couple of weeks ago. Going to try lats next.
 
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Arcygenical said:
Test E/D mix, every 5 days.
I prefer a half dose, 2x frequency IM shot schedule vs the full dose E10D of what I've been prescribed.

For me, that's ~65mg total ester, E5D... Rather than my endo's preferred (and Rx'd) schedule of 125mg Test-C E10D.
Yes, I'm aware 125mg-C/e10D is an odd (underdosed) schedule, but literature does support an endogenous production of Test around the 7mg/day range, which does line up better with a 375mg(esterified) total dosing per month... And my endo is extremely "by the book."

I had horrible withdrawal irritability and acne on an E10D dosing schedule.
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On which ester? Did you try the enthanate/ deconate e10days?
 
Cheapshot said:
On which ester? Did you try the enthanate/ deconate e10days?
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Yep. Around day 8-9, I'd feel very frustrated over minor issues, and get withdrawal acne. Even with the D ester (which supposedly has a longer, ~10.5 day half-life in the body), the acne was unreal, and I don't think we can chalk skin quality up to placebo.

Granted, the mixture I'm using is heavier on the E than D (2:1). But switching to an E5D schedule, at 50% dosage, alleviated mental and skin quality issues.

I've always been very sensitive to E esters. My pet theory is that my body is great at cleaving off that enanthate functional group. I base this off how rapidly I feel sides from other E esterified androgens, well below the established 5.5-7 day expectation. But again, that's a pet theory, and I've no evidence to prove it, other than lived experience.

The Old Guy said:
I started every other day about two months ago and have stopped taking aromasin entirely.

Huberman talked about this on a podcast and it really does seem to work well. Using small 1 ml 25g pins and with small volume it’s easy to inject all over the place. Did pecs for the first time a couple of weeks ago. Going to try lats next.
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So, you take no AI? I rely on an AI (aromasin, 3mg E3D) to look good, but I feel it affects my libido in a way I'm not a huge fan of.
EOD shots, rotating muscle groups heavily? What dosage per shot?

I've recently enjoyed switching to biceps and delts. Surprisingly painless, shooting into your non-dominant arm. And I hate to admit it, but using high mg oils, with EO, makes that annoying smaller bicep look a bit bigger, due to swelling, but that's a toxic mindset, aha.
 
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Arcygenical said:
Yep. Around day 8-9, I'd feel very frustrated over minor issues, and get withdrawal acne. Even with the D ester (which supposedly has a longer, ~10.5 day half-life in the body), the acne was unreal, and I don't think we can chalk skin quality up to placebo.

Granted, the mixture I'm using is heavier on the E than D (2:1). But switching to an E5D schedule, at 50% dosage, alleviated mental and skin quality issues.

I've always been very sensitive to E esters. My pet theory is that my body is great at cleaving off that enanthate functional group. I base this off how rapidly I feel sides from other E esterified androgens, well below the established 5.5-7 day expectation. But again, that's a pet theory, and I've no evidence to prove it, other than lived experience.


So, you take no AI? I rely on an AI (aromasin, 3mg E3D) to look good, but I feel it affects my libido in a way I'm not a huge fan of.
EOD shots, rotating muscle groups heavily? What dosage per shot?

I've recently enjoyed switching to biceps and delts. Surprisingly painless, shooting into your non-dominant arm. And I hate to admit it, but using high mg oils, with EO, makes that annoying smaller bicep look a bit bigger, due to swelling, but that's a toxic mindset, aha.
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Different doctors must have different protocols Mines entirely against a.i. he never perscribes them. I'm yet to have high estrogen but don't want to know what my options would be. He might just lower my dose.
 
Jerbear said:
Different doctors must have different protocols Mines entirely against a.i. he never perscribes them. I'm yet to have high estrogen but don't want to know what my options would be. He might just lower my dose.
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My naturopath loves them. When I’m doubt adex out! Jk
 
Jerbear said:
Different doctors must have different protocols Mines entirely against a.i. he never perscribes them. I'm yet to have high estrogen but don't want to know what my options would be. He might just lower my dose.
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My estrogen is out of reference range on 125mg/week, but I feel great. I do have Aromasin prescription, but I don't plan on using it unless I feel I need it.

Have you tried DIM? On a TRT dose that may be enough for you to lower your estrogen and still keep up the test.
 
Darome said:
My estrogen is out of reference range on 125mg/week, but I feel great. I do have Aromasin prescription, but I don't plan on using it unless I feel I need it.

Have you tried DIM? On a TRT dose that may be enough for you to lower your estrogen and still keep up the test.
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Whats dim? And I think if you feel good but your estrogen numbers are high it's no biggie. I'd think it's more Guaged by how you feel. Some estrogen is definitely bennificial for health
 
Jerbear said:
Whats dim? And I think if you feel good but your estrogen numbers are high it's no biggie. I'd think it's more Guaged by how you feel. Some estrogen is definitely bennificial for health
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DIM is a supplement, it actually is found in small amounts in things like broccoli.

It's been shown to act as a mild, natural aromatase inhibitor. I actually just ordered some for myself, as well I probably could use it!
 
Darome said:
DIM is a supplement, it actually is found in small amounts in things like broccoli.

It's been shown to act as a mild, natural aromatase inhibitor. I actually just ordered some for myself, as well I probably could use it!
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For the record, a female family member who, in her early 30's, endured a double Mastectomy due to intrusion of hormonally (Estradiol) active breast cancer tissue into (AT LEAST) the left breast sentinel node, was recommended DIM supplements from her endo/onc during the monitor period after surgery.

She's too young (apparently, I'm paraphrasing, she's not well versed, medically) for daily Rx AI/blocking treatment like a post-menopausal woman would be, since she's still of child bearing age (and wants a second child); and excision of the hormonally active tissue may very well indicate a low dose of an OTC AI vs a powerful anti-E/AI (like aromasin/letro/tamox) to prevent further development of hormone sensitive invasive tissue and potential metastization.

So, that has to count for something about the efficacy of a properly formulated DIM supplement as a light AI. Personally, I prefer Aromasin or Formestane, but that's from an HRT perspective.

The real issue, for all us HRT patients, is finding a Formestane/DIM supplement we trust to deal with E2 surges from TRT dosing... The repercussions of bunk Amazon supplements are frustrating and embarrassing.
 
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Jayz-23 said:
Does anyone buy into the hype of no Ai needed ever regardless of what your E2 reads on a lab. If you know where I’m going with this is the FB group that does have some pretty good info and knowledge by some in their religiously tries to explain that no Ai is ever needed as the blood test readings is not an accurate way to measure e2 at the tissue level and that e2 is supposed to land and balance where it does in respect to your T level.

I’ve done both lower side of TRT and higher end with and without an Ai. My finding are I feel “better” in general with no Ai but have lackluster libido and zero ercetion quality. With an Ai my body does not feel as good and my joints don’t feel well but have a better erection quality that is better but still hit and miss. I’m a low SHBG guy too and have done everywhere from 1x week to daily and I sorta felt worse on daily oddly enough. Like a constant mental fog. Maybe very stable levels don’t feel well for me I dunno

So my thought is with No Ai I feel better but libido and function is down and attribute that now more test is aromatizing into E2 thus resulting in less Total T and Free T. I’ve upped the T dose to compensate and at that point and didn’t overly seem to feel any better or get more symptom relief. So either it wasn’t going to or I didn’t use enough dosage increase to make up for the higher E2. Crazy cause when I was younger and doing 500mg/wk no Ai I felt great and lots of libido and erections.

I’ve also heard that the higher the E2 it can interfere with thyroid function some and that could possibly be some of the issue then web. No Ai / higher E2 is present.

Thoughts or or others experiences if they felt the same way?
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Have had the exact same experience, and so has my buddy. I never used an AI when I was in my 20s, and no libido issues, ever. My dose right now is 60e4 and I feel like crap. I should feel decent on this dose, but it feels as though I'm taking too little = more anxiety, poorer sleep, low appetite, no drive in the gym. No high E2 symptoms, though. I've also been having some headaches, so I'm going to pin some prop tonight and the next couple days to boost my TT and get this machine back in gear, and I suppose go back to e3. It was the only dosing in which I consistently felt good. That said, I felt very good on 75e4, but I needed ai, that's a given.
 
Nixter said:
120mg test e, split e3d. E2 is a bit over range with this so maybe I could try m/w/f and see if I feel better, if don't want to use an ai
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Hey dude, how's your libido on this split? Have you considered DIM to edge down your E2 rather than resorting to using an AI?
 
35mg daily Test Cyp
33mg primo 3x per week
10mg NPP 3x per week

*ramping up for winter. Normally 175mg/week test is great, split ED to avoid high E2

So, TRT+ hahaha
 
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