too much money for me.most people think of Primo
ugl. I test all of it.using script or UGL HGH
reta works wonders on bg numbershat high of a dose without BG going up / and IGF.
as for the igf, I just read this yesterday
The Genetics of GH Response (ΔIGF-1)
Are You A Hypo- or Non- Responder to GH?
GHR gene polymorphisms
HGH at 4 IU daily increases IGF-1 for most, but some people are hypo- or even non- responders. This fact depends on SNPs in the growth hormone receptor (GHR) gene.
Those who are hyper-responders possess the d3-GHR polymorphism. Population variance in this gene polymorphism can be as high as 50% in some populations. I write more about this in my Bolus HGH book. Search Google or whatever.
But even for d3-GHR GH hyper-responders, rhGH requires 16 – 20 weeks to produce visible physique changes. That's not "slow working" – that's the actual timeline for collagen synthesis and hyperplasia.
Growth hormone stimulates hepatic IGF-1 production, which triggers satellite cell proliferation and differentiation. New muscle cell formation takes 12+ weeks. Collagen deposition in connective tissue requires 20+ weeks of elevated GH/IGF-1.
Guys run GH for 8 weeks and say "it doesn't work." You spent $2000 to barely start the adaptation process. GH effects are dose-dependent AND time-dependent – you need both sufficient dose (4+ IU daily) and sufficient duration (6+ months).
For actual results: 4 IU daily for 6 months minimum. Split AM/PM dosing to mimic pulsatile secretion. Add MK-677 (12.5 mg nightly) to amplify endogenous pulses. If you're not seeing results, find out whether you're d3 null in the GHR gene with genetic testing. There are at least two SNPs that 'tag' the d3-GHR (hyper-response) allele with near certainty, at least in Caucasian/European populations (and perhaps others) and that are also present on most genotyping chips. ncbi.nlm.nih.gov/pubmed… & ncbi.nlm.nih.gov/pubmed…. These SNPs, shown below with the tagging (minor) allele correlated with the d3-GHR allele, are:
rs6873545(C); in 23andMe and other data<br>rs4590183(C) in <a rel="nofollow ugc noopener" target="_blank" href="http://ancestry.com/">ancestry.com</a> and other data<br>
Other relevant genes to endocrinologists considering rhGH treatment in apparent adult GHD: IGF1R, GH1 and others, in addition to d3-GHR (whether exon 3-deleted GHR).

