This is just from my experiences in life.
Partitioning co-efficient,
the miscibility of a powder into an oil is determined by how many carbon atoms are in the powder. The more carbon atoms, then the denser of an oil you need to hold the powder. If the oil is too thin, the the powder won't suspend the powder in the oil, and the two will separate and the powder will 'crash' to the bottom of the container.
So, if you have a powder with few carbon atoms, like test base, it will hold in a thinner oil like grapeseed oil. If you add a bunch of carbon (in the form of esters) to your powder, and you now have a blend of, say, four different types of testosterone, we'll call it Sustanon250, then powder will crash easily in straight Grape Seed Oil (GSO).
How can we dissolve the powder so it stays floating, invisibly, in the oil? Use a solvent. We'll call it Benzyl Benzoate (an insect repellant). So the Benzyl Benzoate (BB) will dissolve the powder, and the BB is insoluble in water, but it mixes well with oil. Infact, it makes the oil (GrapeSeedOil, or whatever oil) thinner and easier to inject. So, now we can add BB to all our mixtures for thinner oil injects and nothing will ever crash!!?! Uh, not yet...
When you inject an oilbased testosterone product into your body you get one of two things: testosterone with NO ester that gives you an immediate spike in test-levels, like Test Suspension does because it has low partitioning; or you have a test with esters attached (carbon attached = high partition) and the carbon esters stop your test levels from spiking and you get a controlled, slow release of test because the test esters stay attached to the oil and the oil takes time to dissipate. The test is gradually hydrolized into the body by things like 5-alpha reductase, which converts the testosterone into DHT.
But, what about the Benzyl Benzoate solvent we added to dissolve our powder into our oil and to stop the powder from separating from the oil once it was dissolved?
In the body, after injection, the Benzyl Benzoate is also affected by the hydrolization process, and the BB inside the muscle breaks-down into benzoic acid and benzyl alcohol. Then the benzyl alcohol is further broken-down into... you guessed it: benzoic acid.
Oops, i forgot to mention that when the powder is added to the oil at the beginning of all this, Benzoic Acid, called BA, is also often added to the mixture as a preservative. But, if the Benzyl Benzoate is already breaking-down and becoming Benzoic Acid, why do we need to add Benzoic Acid in the first place? Or, on the flipside, if we add Benzoic Acid at the beginning of the process, why bother adding Benzyl Benzoate?!?
Remember the definition of partition coefficient:
Partitioning co-efficient,
the miscibility of a powder into an oil is determined by how many carbon atoms are in the powder. The more carbon atoms, then the denser of an oil you need to hold the powder. If the oil is too thin, the the powder won't suspend the powder in the oil, and the two will separate and the powder will 'crash' to the bottom of the container.
So, if you have a powder with few carbon atoms, like test base, it will hold in a thinner oil like grapeseed oil. If you add a bunch of carbon (in the form of esters) to your powder, and you now have a blend of, say, four different types of testosterone, we'll call it Sustanon250, then powder will crash easily in straight Grape Seed Oil (GSO).
How can we dissolve the powder so it stays floating, invisibly, in the oil? Use a solvent. We'll call it Benzyl Benzoate (an insect repellant). So the Benzyl Benzoate (BB) will dissolve the powder, and the BB is insoluble in water, but it mixes well with oil. Infact, it makes the oil (GrapeSeedOil, or whatever oil) thinner and easier to inject. So, now we can add BB to all our mixtures for thinner oil injects and nothing will ever crash!!?! Uh, not yet...
When you inject an oilbased testosterone product into your body you get one of two things: testosterone with NO ester that gives you an immediate spike in test-levels, like Test Suspension does because it has low partitioning; or you have a test with esters attached (carbon attached = high partition) and the carbon esters stop your test levels from spiking and you get a controlled, slow release of test because the test esters stay attached to the oil and the oil takes time to dissipate. The test is gradually hydrolized into the body by things like 5-alpha reductase, which converts the testosterone into DHT.
But, what about the Benzyl Benzoate solvent we added to dissolve our powder into our oil and to stop the powder from separating from the oil once it was dissolved?
In the body, after injection, the Benzyl Benzoate is also affected by the hydrolization process, and the BB inside the muscle breaks-down into benzoic acid and benzyl alcohol. Then the benzyl alcohol is further broken-down into... you guessed it: benzoic acid.
Oops, i forgot to mention that when the powder is added to the oil at the beginning of all this, Benzoic Acid, called BA, is also often added to the mixture as a preservative. But, if the Benzyl Benzoate is already breaking-down and becoming Benzoic Acid, why do we need to add Benzoic Acid in the first place? Or, on the flipside, if we add Benzoic Acid at the beginning of the process, why bother adding Benzyl Benzoate?!?
Remember the definition of partition coefficient:
- the ratio of the concentrations of a solute in two immiscible or slightly miscible liquids, or in two solids, when it is in equilibrium across the interface between them.
Some testosterone powders are mixed with oil, and very little Benzoic Acid is added. So little so, that going as low as 0.9% is acceptable. Bayer only adds 1% Benzyl Benzoate to Testoviron (Test Enanthate) to make 250mg Test-E in Castor oil.
Bayer only adds 1% Benzyl Alcohol to Peanut Oil to make 250mg Sustanon. Pfizer uses 9mg of Benzoic Acid plus 0.1mL of Benzyl Benzoate to make 100mg of Cypionate in Cotton Seed Oil. Best of all is Schering-Plough who makes Nandralone Decoanate 200mg of powder into sesame oil with 5% Benzyl Alcohol.
So, why are different companies using different oils as Carrier Agents for their powders? Well, remember back to partition coefficient and you'll see that different powders with their esters are dissolved differently into oils. And, since people want esterified products that are slowly released into the bloodstream, we need to determine which powder is best suited to match with each different oil.
Three different measures are used to determine the weight or density of oil to determine suitability for use with esters: Saponification Number, Iodine Number, and Refractive Index. In short, Nandralone is best-suited for use with Peanut or Peach Oil. Testosterone Enanthate is a good match with Castor Öl. Cypionate goes well with Cotton Seed Oil. Propionate is a shoe-in for Olive Oil. Tren Acetate blends best with Sesame Oil. Yes, somewhere I have the list of each oil's measurements, and the list also highlights which esters are complimented by which oil. The release of the esters should match the refractive number of the oil (density) because a slow release ester goes well with a slow-dispersion (higher density) oil.
Is it okay to mix a short ester Testosterone Propionate in thin Olive Oil INTO the same syringe as Testosterone Cypionate in Cotton Sseed Oil? Well, if you want your fast release (3carbons) Propionate to be mixed-up with slow release (8carbons) esters to slow the release of your prop then go ahead...but it makes no sense. Mixing different oils and different levels of BA and BB from different products is not recommended. Drug reactions are most likely to occur because of the solvents or preservatives and NOT the active powders.
And, back to the BA and BB issue... does your short ester compound need high amounts of solvents? Maybe not. Big Pharma can't afford for clients to get PIP, so they use as little solvent as possible to reduce the number of reported Adverse Drug Reactions, or they'll be fined and possibly have their DIN certification removed and the product revoked by the FDA. And, physicians don't have a choice to report or not to report drug reactions. In fact, there are file monitoring systems in place to send alerts DIRECTLY to drug manufacturers when patients report reactions.
Looking back at our list, Big Pharma rarely uses Benzyl Benzoate in testosterone compounds with several esters like Polfa's Omnadren, or Organon's Sustanon250. Why is a low concentration of Benzoic Acid the preferred preservative for Big Pharma? Well 1) they want positive reaction from their product; 2) they want to make Big Money from their product. They don't typically manufacture 400-600mg blends because, as one friend from the industry told me during the summer, "the risk is too high for the benefit." He works for Bayer in a foreign country, and his line currently produces, among other things, Testoviron-Depot. He directed me to a clinical study showing that 'patients' had received injections of up to 75% Benzyl Benzoate with no adverse reactions. However, a reaction to BB is either 99% absent or 1% enormous, with very little room for error. But, since product usage, patient safety, patient comfort, and continued sales are paramount considerations, using lowest amounts of Benzoic Acid with zero Benzyl Benzoate makes the most sense and the most cents.
