Steroids and the Heart

Taureau

Administrator
According to researchers, long-term use of anabolic steroids appears to weaken the heart, but it’s not clear if this weakening is reversible.


In an effort to better understand the impact of long-term anabolic steroid use on the heart, cardiologist and researcher Aaron L. Baggish, MD, of Harvard Medical School and Massachusetts General Hospital performed heart function testing on weightlifters – steroid users and non-users. (The study appears in the 4/2010 issue of the American Heart Association journal, Circulation: Heart Failure.)


THE PARTICIPANTS
12 weightlifters that took steroids
7 weightlifters that did not take drugs


Average age: 40
Average length of steroid use: 9 years
Duration of weightlifting, total physical activity level and weight: Groups were similar
Muscle mass: Steroid users had more than the non-users


THE RESULTS
A healthy left ventricle – the heart’s main pumping chamber – pumps 55% to 70% of the blood that fills the heart. This measurement is known as ejection fraction. When Doppler echocardiography ultrasound was used to examine blood flow through the heart, most of the steroid users showed evidence of weakness during contraction in the left ventricle.


  • 10 of the 12 steroid users had ejection fractions of less than 55%, which has been linked to an increased risk for heart failure and sudden cardiac arrest
  • 1 of the 7 weightlifters with no history of steroid use had a low ejection fraction
  • The steroid users also showed evidence of impaired diastolic function, which is the ability of the left ventricle to relax and fill with blood following contraction
  • Left ventricle relaxation was reduced by almost 50% among steroid users compared to non-users
 
So in conclusion, the study shows 1/7 natural weightlifters are liars, just kidding.

Thank you for the read (:
 
Interesting, Wonder what steroids they used? Im sure not everyone was on the same stuff/dose?
 
Hmm interesting. And a littler scary TBH.

I'll have to read the article. I'm interested also in compounds used, dosages etc.
 
What does it matter what compound was used or amount? Chances are we are using the same compounds at higher doses, and these studies show steroids really are bad for our hearts. Something we all knew, but just didn't know to what extent.
 
What does it matter what compound was used or amount? Chances are we are using the same compounds at higher doses, and these studies show steroids really are bad for our hearts. Something we all knew, but just didn't know to what extent.


It does matter because adverse effects and sides are dose dependent for most meds with the adverse effects going up with the increase in dose. There is also the idiosyncratic aspect of reactions to medications/compounds that can't be overlooked which can skew smaller studies.
 
It does matter because adverse effects and sides are dose dependent for most meds with the adverse effects going up with the increase in dose. There is also the idiosyncratic aspect of reactions to medications/compounds that can't be overlooked which can skew smaller studies.
Thank you. I wasn't going to get into it with him.
 

AAS users reported taking median (quartile 1, quartile 3) weekly doses of 675 (513, 950) mg of testosterone equivalent for 468 (169, 520) lifetime weeks.

It is noteworthy that our analysis revealed no significant relationship between cumulative AAS use and cardiac dysfunction. This observation suggests that AAS-associated cardiotoxicity might be only partially and unpredictably related to lifetime dose in a manner similar to the cardiac toxicity of alcohol.
 
AAS users reported taking median (quartile 1, quartile 3) weekly doses of 675 (513, 950) mg of testosterone equivalent for 468 (169, 520) lifetime weeks.

It is noteworthy that our analysis revealed no significant relationship between cumulative AAS use and cardiac dysfunction. This observation suggests that AAS-associated cardiotoxicity might be only partially and unpredictably related to lifetime dose in a manner similar to the cardiac toxicity of alcohol.

Alcohol, eh?
 
What does it matter what compound was used or amount? Chances are we are using the same compounds at higher doses, and these studies show steroids really are bad for our hearts. Something we all knew, but just didn't know to what extent.
Testosterone in moderate dosages would be less deleterious than the various analogues of testosterone.According to Llewelyn.
 
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