I keep going on and off. Aside from orals, only test no ester. I either inhale it with a wearable nebulizer or administer rectally. While using serotonin and endorphin antagonists, I feel 0 suppression (I promised to make a lab but I didnt dose it consistently either and felt no suppression, would be a waste of bloodwork if I don't execute the experimental drugging thoroughly)...
I may have linked 50 studies here and a dozen other relevant awesome studies elsewhere, which made me say that estrogen antagonism is retarded. As an analogy, I would preach that steroids, male and female, do not directly act on pituitary to reduce LH. Rather there are multiple intermediary chemicals, one of which are beta endorphins. I said if naturally we have 100 unit point of endorphins, the mega dosing an estrogen antagonist might at best reduce the endorphin levels by... 30 points? So we have 70, or say it slashes to 50 to be generous. Then, taking exogenous androgens, one study showed that a common athlete's nandrolone dose equivalent in a rodent would raise endorphins in a specific brain region 20 fold. Which means you get what... 2000 unit points of endorphins? Okay this is one single brain region, even if that is countered by other effects of the androgen, just a quarter of it would raise original remaining 50 points plus 400 unit points of endorphins. At 450 points you'll sure be suppressed no less than 500 points without the SERM.
And it's probably unnecessary to preach how endorphins just like exogenous opioids CRASH testosterone levels.
Lemme know if you want all the studies and graphs for that...
But here might be final piece to convince someone that endorphins are necessary for LH suppression to occur...
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.1987.tb01178.x
Just like in that monkey study where a single dose of nalmefene raised testosterone 10 times above normal levels... it's conclusive enough for me.
I DO NOT regret taking steroids especially since I got no side effects, not even any noticeable suppression.
In fact, I found out that the action on brain and muscle volume lasts far longer than the drug stays in the blood. With rectal and aerosol inhaling administration, no matter how high I dose it, the blood concentrations sure must return to baseline before 12 hours. But I definitely benefit for more than 24 hours after a single dose, even at 48 hours normally it still feels like I'm on something... could be elevated DHT? Could be many mechanisms. Lots of food for thought.