GHRP-2

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Administrator
GHRP-2 (Growth Hormone Releasing Peptide 2) is a growth hormone secretagogue of the hexapeptide class. Sharing many similarities with GHRP-6, GHRP-2 is the first in this class of hormones, and in many circles, is considered the better choice between it and GHRP-6. It is not a hormone that is often used alone but is almost always used with a Growth Hormone Releasing Hormone (GHRH) such as PEG-MGF. The compound may also be commonly found under the names Pralmorelin or GHRP Kaken 100. However, in most pharmaceutical and performance based circles, it has in recent years been most commonly referred to as GHRP-2.

GHRP-2 Functions and Traits
GHRP-2 first acts as a Growth Hormone (GH) increasing agent. Comprised of six amino acids, the peptide functions by stimulating natural GH production along with the production and release of ghrelin. The release of ghrelin is important as it also aids in boosting GH release in the body. With GHRP-2, this is accomplished by the peptide suppressing somatostatin, a hormone that limits the release of GH in the body.

As ghrelin is released, the body becomes hungry. GHRP-6 is well known for causing extreme increases in appetite, which may or may not be a problem depending on individual need or goals. GHRP-2 will release the same ghrelin in the body, but should not do so in a way that promotes such a significant increase in hunger. Some increase in appetite is unavoidable, but GHRP-2 does tend to have a far less impact on appetite than GHRP-6. In short, GHRP-2 aids in the promotion of natural GH production in the body, which carries with it numerous performance as well as health benefits for the user.

Effects of GHRP-2
The effects of GHRP-2 can be beneficial to the off-season athlete as it will help with growth. However, when used alone it is going to be a week choice. Off-season athletes will find growth enhanced when used with other performance-based items, and they will find such items are more effective with the presence of elevated levels of GH in the body. Equally important, the individual should be able to maintain a lower level of body fat that often increases during off-season periods of growth due to the necessary caloric surplus needed for muscular growth.

During a cutting phase is when the effects of GHRP-2 may be most beneficial due to increased levels of GH aiding tremendously with fat loss. Individuals with elevated levels of GH in the body provided naturally or otherwise will experience greater levels of fat loss. Due to the increased levels of hunger associated with use, although less than with GHRP-6, some users may find this bothersome. However, hunger is always part of dieting regardless of compounds used.

GHRP-6 is also useful to any athlete or individual on the basis of what elevated levels of GH mean to the human body. Elevated levels of GH carry with it numerous health and physical benefits and may be the primary tool in anti-aging plans. Those who possess higher levels of GH will find the following:

  • More Powerful Metabolism
  • Increased Recovery (post training or any physical activity)
  • Improved Sleep
  • Stronger Immune System
  • Healthier Skin
  • Stronger Bones & Joints
  • Increased IGF-1 (aides in recovery and affects nearly all cells of the human body)
 
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Side Effects of GHRP-2
The side effects of GHRP-2 should not be severe if occurring at all for most individuals if the hormone is used responsibly. However, side effects of GHRP-2 are possible, although much milder than compared to many hormones.

  • Estrogenic: Estrogenic side effects of GHRP-2 should not exist as the peptide does not cause any aromatization. However, gynecomastia in sensitive individuals, particularly those with preexisting gynecomastia is possible. High doses of GHRP-2 may increase prolactin significantly in sensitive men leading to prolactin based gynecomastia.
  • Androgenic: There are no associated androgenic side effects of GHRP-2. Hair loss and acne are not possible. Virilization symptoms in women are not possible with this peptide.
  • Cardiovascular: There are no negative cardiovascular side effects associated with GHRP-2. Many users may find their cardiovascular health improves with elevated levels of GH.
  • Testosterone: GHRP-2 will not suppress natural testosterone production.
  • Hepatotoxicity: GHRP-2 is not toxic to the liver and will produce no liver damage.
For those who use GHRP-2, the most common side effect will be an irritated injection site. This will normally remedy itself by finding new areas of the body to administer the peptide. Some users may also experience swollen ankles or wrist as well as carpel tunnel like symptoms when use first begins. Lowering the dose and easing into higher doses if necessary can normally remedy such issues. Some users may also find issues with blood sugar control and may need to adjust their diets accordingly. Such blood sugar issues may produce mild to severe headaches. Elevated levels of cortisol are also possible but are normally only associated with very high doses, such doses should be avoided.

GHRP-2 Administration
GHRP-2 will come in dry powder (Lyophilized) form and will be reconstituted with bacteriostatic water. It may be found as an individual item or as part of an overall GHRH mixture. Some pharmacies provide GHRH compounds with added GHRP-2 or GHRP-6. The compound may be injected subcutaneously or intramuscularly depending on individual preference. Once reconstituted, GHRP-2 must be kept refrigerated.

GHRP-2 can be used indefinitely and will normally be used continuously in anti-aging plans that call for it with a GHRH. Dosing can range dramatically depending on need with 100-300mcg per day being commonplace. If used with a GHRH, which is recommended, the dose may often be towards the lower end of the scale. For optimal results, the user will find two injections per day on an empty stomach to be best. If done subcutaneously this should prove to be the easiest method as it will be the least intrusive.
 
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here is some more

Uses


Improve sex drive and desire by stimulation of hypothalamus
Reduces belly fat through lipolysis
Increases energy and vitality
Improves skin elasticity, ridding wrinkles
Increases endurance
Accelerates healing from wounds or surgery
Strengthens the heart
Enhances the immune system
Increases IGF-1 production, by as much as 50% in first week
Improves sleep quality
Increases calcium retention, strengthens and increases the mineralization of bone, bone density
Increases protein synthesis,
Improves eyesight and vision
Reduces liver uptake of glucose, an effect that opposes that of insulin
Promotes liver glucogenesis
Contributes to maintenance and function of pancreatic islets


GHRP2 growth hormone releasing peptide therapy is considered one of a few medical means of reversing the effects of aging in adults deficient in growth hormone. This is because of the benefits resulting from the increased stimulation and secretion of human growth hormone by the pituitary gland hypothalamus,axis HPA.


GHRP-2 also known as KP 102 is a commercially synthesized, growth hormone releasing hexapeptide. It is a super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol).


Growth Hormone Releasing Peptide 2(GHRP-2) substantially stimulates the pituitary gland’s increased natural production of the body’s own endogenous human growth hormone (hgH). This therapy consists of daily periodic sub-lingual dosing. Growth Hormone releasing peptide 2, GHRP-2 has shown on it’s own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone (GHRH) to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.


GHRP-2 is a true hgH secretagogue. It stimulates the body’s own secretion of hgH as explained herein. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects. It has a short half life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.


Growth hormone releasing peptide is a commercially synthesized, non-natural super-analog of the GHRP-6 which is capable of potent stimulatory effect on growth hormone (GH) secretion with slight stimulator effect in PRL, ACTH and levels of cortisol (Arvat et al. 1997). It is also a synthetic agonist of ghreline that is binding with the growth hormone (GH) secretagogue receptor. GHRP-2 has been shown to affect and induce growth hormone secretion. The response of natural physiologic system includes increase in levels of calcium ion influx alongside with increased release of growth hormones in response to this peptide (Wu et al. 1994). Its chemical structure and other chemical properties are described below:


Furthermore, dose-dependent investigations have proven that this analog is similar in terms of potency with GRF and was even tenfold more potent than earlier generations of GH-releasing secretors such as GHRP-6 and GHRP-1 (Wu et al. 1994). Because of such effects, this hormone has been used for the treatment of different monkey deficiencies and catabolic states. Studies of Laferre et al. (2005) have shown that GHRP-2 acts like ghrelin which induces food intake in monkeys and also stimulates GH secretion. This has been demonstrated when GH levels rose significantly during GHRP-2 infusion (AUC 5550 ± 1090 µg/L/240 min vs. 412 ± 161 µg/L/240 min, p = 0.003). Also, GHRP-2 has shown to be inducing secretion of cAMP in cells in a manner similar to that of GRF. GHRP-2 supplication has also acted as an anti-inflammatory effect in arthritic rats and seems to be mediated by ghrelin receptors directly on immune cells (Granado et al. 2004). However, it is important to note that the level of results with the action of GHRP-2 differs accordingly with species specifically in the response of the pituitary somatotrophs probably because of differences in the subtypes of GHRP receptors (Wu et al. 1996). Its action however in the physiologic system is blocked by GRF receptor antagonist which acts through a different receptor to that employed by earlier GHRPs.
 
GHRP2 is quite powerful at 250-400 mcg.GHRP 6 I get hungry immediately.GHRP 2 the hunger starts building after 15-20 minutes.At 40 mins I eat the house.:)
 
I tried some a few years ago. Biggest problem for me was the hunger. Makes it very hard to eat well when you are starving.
 
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